Integrative Metallomics Studies of Toxic Metal(loid) Substances at the Blood Plasma–Red Blood Cell–Organ/Tumor Nexus

Globally, an estimated 9 million deaths per year are caused by human exposure to environmental pollutants, including toxic metal(loid) species. Since pollution is underestimated in calculations of the global burden disease, actual number pollution-related likely be substantially greater. Conversely, anticancer metallodrugs deliberately administered cancer patients, but their often dose-limiting severe adverse side-effects necessitate urgent development more effective that offer fewer off-target effects. What these seemingly unrelated events have common our limited understanding what happens when each substances enter bloodstream. However, bioinorganic chemistry unfolds at plasma/red blood cell interface directly implicated mediating organ/tumor damage and, therefore, immediate toxicological and pharmacological relevance. This perspective will provide a brief synopsis AsIII, Cd2+, Hg2+, CH3Hg+ metallodrug cisplatin Probing processes near-physiological conditions integrating results with biochemical within organs and/or tumors has potential causally link chronic species disease etiology translate novel metal complexes clinical studies, which significantly improve health 21st century.